Study Overview.

This is a multi-center, randomized open-label pilot study designed to evaluate the acceptability and feasibility of a multicenter randomized trial comparing aggressive antibiotics (increased airway clearance plus initiation of oral antibiotics for 14 days) versus tailored therapy (increased airway clearance alone, with addition of antibiotics for worsening symptoms, or failure to improve by day 7) for oPEx treatment in children with CF.

The primary objective is to estimate the proportion of participants randomized to a tailored therapy arm that has no antibiotic exposure during the 28-day exacerbation period. We will meet these objectives by enrolling patients during a well-child CF clinic visit or over the phone.